Search results for " Experimental pain"

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Is pain sensitivity altered in people with Alzheimer's disease? A systematic review and meta-analysis of experimental pain research

2016

Background Clinical studies suggest people with Alzheimer's disease (AD) have altered pain sensitivity. Experimental pain research is equivocal. Objective Conduct a meta-analysis to investigate if people with AD have altered pain sensitivity compared to healthy controls (HCs). Methods Three authors searched electronic databases from inception till November 2015 for experimental pain studies in AD vs. HCs. Outcome measures were pain threshold, tolerance, pain ratings, heart rate response to noxious stimuli and the Facial Action Coding System (FACS). Random effect meta-analysis calculating Hedges' g ± 95% confidence intervals (CI) was conducted. Results Thirteen studies were identified, inclu…

Dementia painAgingmedicine.medical_specialtyPain toleranceBFPainDiseaseBiochemistryExperimental pain03 medical and health sciences0302 clinical medicineEndocrinologyAlzheimer DiseaseHeart RateInternal medicineThreshold of painGeneticsmedicineNoxious stimulusHumans030212 general & internal medicinePsychiatryMolecular BiologyAlzheimer's disease; Dementia pain; Experimental pain; Meta-analysis; Systematic review; Aging; Biochemistry; Cell Biology; Endocrinology; Genetics; Molecular BiologyPain MeasurementFacial expressionMini–Mental State Examinationmedicine.diagnostic_testbusiness.industryCell BiologyAlzheimer's diseaseConfidence intervalMeta-analysisMeta-analysisSystematic reviewAlzheimer's disease; Dementia pain; Experimental pain; Meta-analysis; Systematic reviewAlzheimer's disease Dementia pain Experimental pain Meta-analysis Systematic reviewbusiness030217 neurology & neurosurgeryExperimental Gerontology
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